Associate Scientist II, Molecular Screening and Characterization

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Job Description

Drug Discovery addresses key unmet medical needs through the identification and validation of therapeutic targets, generation of leads, and optimization of those leads into drug candidates for clinical evaluation. We are seeking a highly talented and motivated scientist to join our molecular screening and characterization group in the Target Enabling Technology area. This group focuses on assay development, optimization, and execution of in vitro biochemical and cell based high throughput screens and providing assay support for SAR and mechanistic studies for multiple therapeutic areas. The individual should have strong molecular biology/cell biology across various target classes and will work with multiple disease biology groups to develop, optimize, and execute novel assays in various disease models that can be utilized in a high-throughput screening format. In this role, he/she/they will work closely with project team members to implement in vitro screening strategies as part of the overall project plan. The candidate should play an active role in communicating and collaborating with scientists across AbbVie to advance projects through day-to-day interactions, presentation of data, and interpretation of results.

Key Responsibilities:

• Develop in vitro assays, screening strategies, mechanistic studies, deliver high quality data from validated screens to drive lead series identification and lead optimization. The successful candidate will develop disease-relevant phenotypic assays using complex cellular models such as primary and stem cells and elucidate mechanism of action of molecules.
• Proficiency with multiple assay formats in higher throughput format
• Engage and collaborate with multiple disease area teams and make substantial contributions to the conception and execution of screens including mechanism of action studies within strict time and quality tolerances.
• Collaborate actively within the group and cross functional team to execute projects and coordinate discovery efforts.
• Maintain cutting-edge awareness of technical developments and scientific knowledge and proactively, applying these when appropriate.
• Effectively communicate results in presentations and written reports and actively participate in cross-functional teams.

Qualifications

Qualification:

• Master's degree in biology, biochemistry, biomedical sciences, or related field with experience in a drug discovery laboratory or Bachelor's degree in biology, biochemistry, microbiology, or related field with typically 3 years of experience in a drug discovery laboratory setting working as part of a multi-disciplinary team.
• Demonstrated experience in biochemical and cellular assays, such as protein-ligand binding, enzyme activity and functional cell assays.
• Skills in mammalian cell culture, cell transfection, immunofluorescence imaging, and western blotting.
• Able to think critically and creatively across multiple disciplines. Demonstrated ability to solve research problems with experience in standard in vitro assays including assay development, optimization, and troubleshooting.
• Able to analyze and critically interpret and report data and research conclusions.
• Ability to multi-task and successfully interact with a diverse team of scientists to deliver results meeting the needs of various stakeholder groups.
• Capable of working independently while contributing and participating in a team environment.
• Excellent oral and written communication skills.

Preferred Experience:

• Familiarity with assay technologies, automation, and high throughput screening approaches.
• Experience in FLIPR, signaling assays and target Engagement assays preferred.
• Computational skills enabling automated data acquisition and analysis, and familiarity with related software applications, for example Spotfire.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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