Instructor, Molecular & Cellular Biology - Rosen Lab

Division: Molecular and Cell Biology

Work Arrangement:

Location: Houston, TX

Salary Range:

FLSA Status: Exempt

Work Schedule:

Summary

The lab of Dr. Jeff Rosen research is based upon the philosophy that it necessary to first define the mechanisms regulating normal mammary gland development in order to understand the alterations in breast cancer. Specifically we have been interested in characterizing the role of Wnt and Fgf family members in normal mammary gland development and stem cell self-renewal, and the properties of tumor initiating cells including the mechanisms of resistance to standard of care therapies. We have a long history of developing syngeneic preclinical genetically engineered models of triple negative breast cancer that have been extensively characterized using different omics platforms and more recently with respect to their immune microenvironments. These models are being used to study critical questions of tumor heterogeneity, dormancy and recurrence with a focus on the treatment of metastatic triple negative breast cancer.

A junior Faculty position is available immediately in the laboratory of Dr. Jeff Rosen with the following job duties: Increased macrophage infiltration is associated with poorest outcome following neoadjuvant chemotherapy (CTX) in patients with triple negative breast cancer (TNBC). In contrast, patients with increased tumor infiltrating lymphocytes (TILs) and fewer macrophages achieve a favorable pathological complete response (pCR). In the metastatic setting macrophages continue to accumulate to promote tumor survival and play a key role in therapeutic resistance. In order to understand the synergism between macrophages and tumor cells within the Tumor Immune Microenvironment (TIME), it is essential to have appropriate immunocompetent preclinical TNBC models that represent the high Epithelial-to-Mesenchymal (EMT)/ Macrophage phenotype observed in patients with a poor prognosis. We propose to spatially profile the metastatic TIME of lung and liver metastases following, anti-CSF1R (SNDX-ms6352) with CTX and newly approved anti-PD1 in order to identify mechanisms of resistance that lead to ITH using our unique p53 null mouse models. Further we will explore if targeting existing metastasis can recruit TILs including antigen presenting dendritic, B and T cells and convert "cold" tumors "hot" leading to a durable antitumor long-term response The ideal candidate should be highly motivated, well organized, manage time effectively, and have the ability to work independently as well as part of a team. She/He will also be required to conduct experimental research lab work and assist in the design of one or more specific phases of entire projects.

Job Duties

• Follow overall research objectives and protocols to design, set-up, conduct, and troubleshoot experiments
• Evaluate protocols and data obtained from experiments and recommends changes to processes, procedures and techniques to improve the quality and validity of results based on project objectives
• Prepare and conducts laboratory research experiments.
• Prepare and seek additional grant funding for the research project(s)
• Write and submit manuscripts

Minimum Qualifications

• Post-terminal degree education (e.g., residency, postdoctoral training/fellowships).

• Outstanding interpersonal and communication skills and the ability to work independently and in a team environment
• A record of taking initiative to solve problems and working to high-quality standards
• Attention to detail and accurate record keeping
• Ability to multitask, work and learn independently, and be self-motivated
• Demonstrated ability to follow detailed instructions as required by research protocols
• Demonstrated ability to learn new technologies
• Demonstrated computer skills, including spreadsheets and basic computations
• Manual dexterity

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

Requisition ID: 20459