Principal Scientist, Chemistry Automation

Billerica, Massachusetts


Employer: Merck Group
Industry: 
Salary: Competitive
Job type: Full-Time

  As the Principal Scientist, Chemistry Automation, you will be part of the Drug Discovery Automation group responsible for designing, managing, and leading the automated chemistry synthesis systems, part of our cutting-edge cloud lab infrastructure providing drug discovery and chemistry services to Pharmaceutical and Biotech customers. The ideal candidate will have a strong background in organic chemistry and experience developing and implementing automated chemistry synthesis systems and processes in pharmaceutical R&D settings. You will be responsible to:Lead the design, development, and implementation of new automated, high throughput chemistry synthesis systems for medicinal chemistry applications.Transfer chemical synthesis procedure in to automated chemistry protocols, troubleshoot and optimize new synthetic methodologies in line with project chemistry requirements.Plan and execute experiments to optimize the efficiency and reproducibility of chemistry synthesis systems, purification and characterization of intermediates and final compounds.Collaborate with cross-functional teams, including process engineers and software developers, procurement, sourcing, facilities, and project management. Develop and implement quality control procedures to ensure that chemistry synthesis processes are carried out accurately and consistently.Lead automation project planning, timeline, milestones, success criteria and resources management including engineers, equipment, lab space etc. for new lab build-outs.Develop and manage the laboratory's budget, ensuring that all expenditures are justified and aligned with the laboratory's goals and objectives.Prepare and present technical reports, research findings, and presentations to internal and external stakeholders. Location: Billerica, MA; HybridTravel: <10% Who You Are: Minimum Qualifications:MS degree in organic chemistry, medicinal chemistry, chemical engineering or related fieldsAt least 3 years of relevant experience in small molecule synthesis, catalysis, flow chemistry, and chemistry automation in the pharmaceutical/biotech industryHand-on experience in automated synthesis workflows, including solid/liquid handling platforms, automated reaction execution tools and purification solutions.Knowledge of analytical instrumentations such as HPLC/MS, SFC/MS, with the ability to develop creative solutions to complex chemistry synthesis challenges.Excellent communication and interpersonal skills, with the ability to work effectively with customers, suppliers, and other stakeholders. Preferred Qualifications:PhDStrong experience in implementing automated chemistry synthesis processes, including the use of robotic systems.Detailed knowledge of scheduling software design and integration across an automated laboratory environment.Experience with automation project development from concept, preliminary and final design, through construction, installation and project closure strongly preferred with cost analysis.Comfortable working in an entrepreneurial environment, agile and face-paced teamsSelf-driven, results-oriented leader with proven collaborative working style  

Created: 2024-07-01
Reference: 275331
Country: United States
State: Massachusetts
City: Billerica