Research Technician II, Yao Lab

Research Technician II, Immunology, Yao Lab

Why UT Southwestern Medical Center?

With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. At UT Southwestern, we invest in you with opportunities for career growth and development that align with your future goals and help to provide security for you and your family. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more that are all available on the day you start work. UT Southwestern is honored to be a Veteran Friendly work environment that is home to approximately 800 veterans. We value your integrity, dedication, and the commitment you've made to our country. We're proud to support your next mission. Ranked by Forbes as one of the Top 10 National Employers, we invite you to be a part of the UT Southwestern team where you'll discover teamwork, professionalism, and consistent opportunities for growth.

Immunology

The Immunology Department at UT Southwestern provides excellent opportunities for training in the concepts and techniques of contemporary biomedical sciences. Our mission is two-fold: advance knowledge and understanding of disorders of the immune system, and train future generations of scientists. These dual functions make the Department of Immunology a key contributor in UT Southwestern's promise of delivering the future of medicine, today.

The Lab of Dr. Chen Yao has a long-term goal to identify molecular and cellular mechanisms that determine the efficacy of vaccines and immunotherapies against infectious diseases and cancers. There are two major directions in the Yao Lab:

1. Long-term T cell immunity is critical in combating chronic viral infection and cancer. We have found that transcription factors TOX and BACH2 are critical for the formation of stem-like CD8 T cells and the development of long-term immunity. We will dissect the molecule targets of TOX and BACH2 that mediate their function in T cells.
2. Immunotherapy has revolutionized the treatment of patients with renal cell carcinoma (RCC). However, only a minority of patients with RCC achieved complete responses after immunotherapies. In the Yao Lab, we aim to understand the T-cell intrinsic and extrinsic mechanisms that determine their antitumor responses induced by immunotherapies. Using mouse RCC models and patient samples, we will identify and validate prognostic biomarkers for immunotherapies against RCC. In addition, we will use gene-editing technologies to uncover and validate novel pathways that can be targeted to enhance antitumor T-cell responses during cancer immunotherapies

Job Summary

A Research Technician II position is available in the Yao Lab in the department of Immunology at UT Southwestern Medical Center. The ideal candidate will have experience with handling mice.

Experience and Education

• Master's degree with major coursework in field of assignment and no experience required OR
• Bachelor's degree with major coursework in field of assignment and one (1) year research experience at level of Research Technician or equivalent OR
• Two (2) years college with emphasis in coursework in field of assignment and four (4) years research experience including two (2) years at level of Research Technician or equivalent OR
• High school graduation or GED and six (6) years research experience to include two (2) years at level of Research Technician or equivalent.

Lab Duties

• Provide general support to laboratory staff and PI
• Maintain the laboratory and equipment in working and clean conditions.
• Maintain laboratory compliance to safety regulations.
• Collects, accurately records and analyzes data in conjunction with other research staff.
• Isolate, maintain, and culture tumor cells and T cells.
• Genotype and phenotype mice. Prior experience with mice is highly recommended.
• Maintenance of mouse colony. Previous experience with mouse handling is preferred.
• Perform flow cytometric analyses
• Perform PCR and DNA cloning analyses.
• Process cancer patient samples.
• Order reagents and materials and oversee inventory.
• Maintains laboratory records, supplies, samples in an organized manner.
• Take part in lab meetings and present data.
• Perform other tasks, as needed.

Job Duties

• Performs routine scientific and medical research work in science area such as biology, chemistry, physics or other related scientific field.
• Assembles and/or operates various laboratory equipment and supplies.
• Records research data in accordance with prescribed procedures, discussing results with supervisor.
• Assists in collection of data for project reports.
• Reads literature and confers with supervisor concerning implementation of new procedures.
• May plan for, and provide working supervision to, work of laboratory personnel of lower grade engaged in limited phase of research project.
• Performs other duties as assigned.

To learn more about the benefits UT Southwestern offers, visit https://www.utsouthwestern.edu/employees/hr-resources/

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.