Lab Specialist in Cardiovascular Functional Genomics - Center for Public Health Genomics

The Miller Laboratory at the University of Virginia seeks a highly motivated Laboratory Specialist with a background in the life sciences (e.g. genetics, molecular biology, cell biology, developmental biology, engineering or similar fields) to investigate the genomic and epigenomic basis of inherited vascular diseases and cardiomyopathies. Our group has recently investigated the causal mechanisms of genetic loci associated with coronary artery disease and related cardiovascular diseases, with a focus on understanding the regulation and targeting of mural cell signaling pathways ( Wong et al Circ Res 2023; Turner et al Nat Genet 2022 ). These efforts are expected to reveal the 'hidden risk' for cocardiomplex diseases for more precise prediction and early-stage prevention.

The successful candidate will be expected to:

• Performing molecular biology assays (e.g. CRISPR/Cas9 genome editing), cell culture (monolayer or 3D organoids), and histology/immunohistochemistry assays.
  
• Contribute to the generation and computational analysis of single-cell (e.g. snRNA-seq, snATAC-seq) and spatial genomics datasets from both normal and diseased environments, in order to study mural cell regulation and disease mechanisms.
  
• Work largely independently on protocol optimization, data collection and analysis and collaborate on multiple team projects.
  
• Benefit from a highly interactive environment in the Center for Public Health Genomics , with strong collaborations with nearby labs and members of the Robert M. Berne Cardiovascular Research Center.
  

To learn more about the position and the research please contact Dr. Clint Miller, clintm @virginia.edu

Minimum Qualifications :

• Bachelor's degree.
  
• 3 years of experience. 6 years of lab-related experience accepted in lieu of degree.
  

Preferred Qualifications:

• Excellent written and oral communication skills is required, as is excellent organization and management skills.
  
• Experience in human genetics, molecular biology, engineering, or similar field is preferred.
  
• Knowledge of statistical genetics and next generation sequencing analyses is preferred.
  

This position is a restricted position and is dependent upon project need, availability of funding and performance This is Non-Exempt level, benefited position. For more information on the benefits at UVA, visit hr.virginia.edu/benefits .

This position will remain open until filled. The University will perform background checks on all new hires prior to employment. A completed pre-employment health screen is required for this position prior to employment.

This position will not sponsor applicants for work visas.

Physical demands:

This position can spend extensive periods of time standing and squatting while conducting experiments or caring for animals. Also requires keyboarding and other bench work and animal procedures requiring finer finger manipulation.

To Apply:
Please apply through Workday, and search for R0048523 . Internal applicants must apply through their UVA Workday profile by searching 'Find Jobs.' Complete an application online with the following documents:

• CV
  
• Cover letter
  

Upload all materials into the resume submission field, multiple documents can be submitted into this one field. Alternatively, merge all documents into one PDF for submission. Applications that do not contain all required documents will not receive full consideration.

For questions about the application process, please contact Yelena Markazyan, Academic Recruiter, ym3mm @virginia.edu .

This position is located in Charlottesville, VA. For more information about UVA and the Charlottesville community please see http://www.virginia.edu/life/charlottesville and https://embarkcva.com/.

The University of Virginia, i ncluding the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician's Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.