About City of Hope

City of Hope is an independent research and treatment center for diabetes, cancer and other life-threatening diseases. Bringing together the best in bench-to bedside research, City of Hope's Arthur Riggs Diabetes & Metabolism Research Institute (AR-DMRI) is one of the world's most comprehensive diabetes research programs.

City of Hope has a long and impressive history of groundbreaking discoveries in the field of diabetes spanning more than five decades since Rachmiel Levine, M.D., who discovered the role of insulin in glucose transport, launched diabetes research at City of Hope in the 1970s. The Institute is named for Arthur D. Riggs, Ph.D., another pioneer in the field famous for his work on synthesizing the first man-made gene and using synthetic genes to produce human insulin, now the standard of care for people with diabetes worldwide. The AR-DMRI is headed by Debbie Thurmond, Ph.D., a renowned research scientist, professor and founding chair of the Department of Molecular & Cellular Endocrinology.

City of Hope is also home to seminal National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) programs, such as the Human Islet Research Network (HIRN) and the Integrated Islet Distribution Program (IIDP), that lead the field of diabetes in diabetes research and translational potential.

City of Hope is located in Los Angeles, California, with community clinics throughout Southern California. It recently acquired Cancer Treatment Centers of America, extending its national reach. One of only 53 NCI-designated comprehensive cancer centers in the nation, it has been ranked as one of "America's Best Hospitals" in cancer by U.S. News & World Report for over 15 years. Founded in 1913, City of Hope is a pioneer in the fields of immunotherapy and clinical islet cell transplantation for diabetes, bone marrow transplantation and numerous breakthrough cancer drugs, many based on technology developed at the institution.

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary:

Under the supervision of Dr. Anna Wu, the Research Associate II (RAII) will perform a variety of research experiments that involve protein expression and characterization, tumor cell lines/ tissue culture, mouse tumor models, and imaging and therapy studies. The RAII should be interested in reading scientific articles, contributing original ideas to the laboratory research; compiling reports of laboratory experiments and results; standardizing new techniques and training other staff on these techniques.

Protein biochemistry skills that are used in the lab include protein expression, purification (chromatography), characterization (ELISAs, flow cytometry, SDS-PAGE), conjugation, and radiolabeling. Mammalian cell culture is employed for protein production, functional assays, and tumor induction. Preclinical studies will involve tumor implantation and monitoring, in vivo imaging, tissue harvest and immunological profiling, and therapy studies including targeted radionuclide therapy.

Research in the Wu lab spans basic and translational science in a collaborative, interdisciplinary, and dynamic environment that values initiative, communication, professionalism, and teamwork. Dr. Wu is eager to mentor scientists of all backgrounds who want to go on to develop a productive career in academic medicine or science and will provide opportunities to help the RAII achieve their career goals.

Key Responsibilities include:

• Utilize established protocols to perform a variety of research experiments, both in vitro (in cancer cell lines) and in vivo (in murine models). Record and validate results for accuracy and completeness.

• Maintain thorough and accurate records of methodology and results. Analyze, compile, and graph data to present at lab meetings.

• Ensure that all laboratory activities are carried out in compliance with safety procedures and guidelines.



Basic education, experience and skills required for consideration:

• A Bachelor's degree with 2 years of experience or Master's with 1 year of experience is required.

• Experience with protein biochemistry, radiolabeling, cell culture and murine models is preferred.

• A desire to work in a collaborative, interdisciplinary lab environment that values communication, initiative, professionalism and teamwork.

Additional Information:

• The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

• As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

• Dr. Wu's research is currently supported by an NIH R01 grant from the National Cancer Institute and internal funds from City of Hope.

• Research findings from Dr. Wu and colleagues have been published in Cancer Research , Clinical Cancer Research , Molecular Cancer Therapy , Journal of Nuclear Medicine, Proceedings of the National Academy of Science , and numerous other journals.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.