Mouse Immunotherapy Research Technician

The Mouse Immunotherapy Research Technician will participate in research studying the beneficial and harmful effects of T cells in the context of bone marrow transplantation and adoptive T cell immunotherapy of cancer. T cells from the bone marrow transplant donor can attack leukemia cells, but they also can damage normal tissues causing graft-vs-host disease. Understanding the biology of these processes is key for improving outcomes in the clinic. Similarly, T cells can recognize mutant proteins in cancer cells, but this process is not naturally strong enough to prevent cancer. The lab studies the nature of T cells that infiltrate tumors and the creation of T cell products that target these mutant proteins. The new hire will work with novel gene modified mice (including those made by the PI), CRISPR-editing of mouse leukemias, adoptive T cell immunotherapy, high-throughput genomic techniques and state of the art mouse model systems. The candidate will be trained in some or all of the following areas: molecular and cell biology techniques, the handling of mice and the principles of cellular and molecular immunology as they relate to blood and marrow transplantation and cancer immunology.