Postdoctoral Fellow - Genetics (Guarnerio lab)

The Guarnerio lab is looking for talented and motivated postdoctoral fellows to join our dynamic team.

At the Guarnerio lab, we're dedicated to unraveling the complex molecular mechanisms used by tumor cells to create a pro-tumorigenic tumor microenvironment (TME). We utilize cutting-edge technologies like single-cell RNA sequencing and spatial transcriptomics to study both mouse and human tissues. Our research is deeply rooted in translational science, with the ultimate goal of developing innovative cancer therapies that reprogram tumor cells and the TME.

Our recent publications include:
Study of the MIF/CD74 axis in pro-tumorigenic macrophages (Tessaro et al., Cell Reports, 2022)
Identification of anti-inflammatory, tumor promoting circular RNAs (Piras et al., Nat Comm, 2022)
Characterization of glyCAFs and T cell exclusion from the tumor mass (Broz et al., Nat Comm, 2024)

Research Projects:
Postdoctoral fellows will have the opportunity to lead independent research on one of these exciting projects:
Cancer-Associated Fibroblasts (CAF): Investigate their role in promoting tumor growth and immune exclusion.
Circular RNAs: Explore novel mechanisms of immune exclusion and evasion.
Sarcoma Stem/Progenitor Cells: Identify new tumor vulnerabilities and therapeutic targets.

LEARNING OBJECTIVES
As a postdoc, you will:
Lead your project and collaborate with internal and external teams.
Mentor PhD students and present findings at lab meetings, seminars, and conferences.
Publish your research in peer-reviewed journals.
Gain expertise in cancer biology, immunology, single-cell RNA sequencing, data analysis, and grant writing.

ELIGIBILITY REQUIREMENTS
Recent Ph.D. in cancer biology or immunology with lead-author publications.

Excellent communication skills and the ability to work independently in a team.

Experience in cancer immunology, murine tumor modeling, and/or tumor/immune metabolism is desirable. Strong experience in flow or mass cytometry is a must.

Familiarity with single-cell RNA-sequencing and functional genomics (e.g., CRISPR/Cas9 pooled screenings) is a plus but not required.

Candidates pursuing an independent career path are preferred.

ADDITIONAL APPLICATION INFORMATION
Interested applicants should email to JGuarnerio@mdanderson.org the following:

1. 1-page cover letter detailing your career objectives and research interests.
2. CV with a selected publication list (max. 3 pages).
3. Names of three references.

POSITION INFORMATION
MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000 . depending on the number of years of postgraduate experience. MD Anderson trainee compensation also includes:

Paid medical benefits (zero premium) starting on the first day for trainees who work 30 or more hours per week
Group dental, vision, life, AD&D, and disability coverage
Paid education, vacation, and sick leave
Paid institutional holidays, wellness leave, childcare leave, and other paid leave programs
Teachers Retirement System defined-benefit pension plan and two voluntary retirement plans
Employer-paid life, AD&D, and an illness-related reduced salary pay program
Health Savings Account and Dependent Care Reimbursement flexible spending accounts
Fertility benefits
State of Texas longevity pay
Extensive wellness, fitness, employee health programs, and employee resource groups

FACULTY MENTOR
Jlenia Guarnerio, PhD