About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

A Staff Scientist position is available at the Beckman Research Institute of City of Hope in the laboratory of Prof. John Williams.

The Williams lab focuses on structure-based protein engineering and its application to generate next-gen biologics to address unmet therapeutic needs for cancer and T1D patients.

Ongoing efforts include the development and expansion of the meditope technology (discovered in the Williams lab), using it to address antigen escape (doi: 10.1136/jitc-2021-003752), the development and optimization of antibody-drug conjugates (doi: 10.1038/s41467-018-03976-5 and doi: 10.1021/acs.bioconjchem.8b00284), and pre-targeted imaging and treatment with radionuclides. The lab is also involved in the development of disease-activated biologics, including immunotherapeutics (technologies that led to the founding and development of Xilio Therapeutics, Inc.) and antibody and TCR discovery (combining single cell technologies and biophysics to produce biologics for novel targets: doi: 10.1016/j.immuni.2022.10.019).

The lab is well-funded and exceptionally equipped to rapidly advance discoveries to IND-enabling studies and the clinic.



Basic education, experience and skills required for consideration:

• Must have at a minimum, the U.S. equivalent Bachelor's or Master's degree in an appropriate discipline, and will often have a Ph.D. or other doctoral level degree.

• Requires expert knowledge in protein production (e. coli, insect cell, and mammalian), purification (including FPLC and HPLC chromatography), biophysical characterization (SPR, DSF, ITC), and structural biology (at a minimum, X-ray crystallography - cryoEM is a plus).

• Must keep meticulous notes and is expected to communicate effectively, both verbally and in writing.

• Highly creative and productive, working harmoniously within a large team of graduate students, postdocs, research professors, and staff scientists. In return, the candidate will gain exposure to discovery, development, and IND-enabling work with the potential to develop life-saving medicines.

Additional Information:

The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

For more information, visit the John Williams, PhD website .

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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