Postdoctoral Research Fellow

GENERAL SUMMARY/ OVERVIEW:

The laboratory of Dr. Haobo Li is seeking a post-doctoral research fellow with training in molecular biology and small animal work, preferably in the context of cardiovascular and/or aging and diabetes research. The lab is located on the Boston campus of the MGH Department of Anesthesia (Edwards Research Building). The laboratory investigates mechanisms that drive aging/diabetes and heart disease as well as cerebral disease, through genetic, pharmacological, and physiological (i.e. exercise) interventions. The selected candidate will join an extraordinary group of talented and motivated basic and clinical scientists whose work has direct translational applications and is linked to potential novel therapeutics. Additionally, he/she will be fully integrated into the outstanding biomedical research environment at MGH and Harvard Medical School, and participate in active collaborations with the Broad Institute, MIT, Joslin Diabetes Center, and the Boston Pepper Center.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

The candidate will be mentored by Dr. Haobo Li, PhD. The specific projects he/she will be working on will be focused on investigating fundamental mechanisms of (1) biological aging that contribute to frailty and cardiovascular disease; or (2) how diabetes leads to the development and progression of diabetic cardiomyopathy. The projects will largely build off the lab's recent publications (Li et al, Circulation, 2022; Li et al, Circulation Research, 2020; Kang et al, AJP-Heart, 2024), which identified long noncoding RNAs and age-related biological pathways involved in cardiac aging, frailty, and heart failure. Scientific investigations will include work in both human biospecimens and preclinical animal and cell culture models. Extensive training in advanced molecular biology techniques, high throughput transcriptomic and proteomic screening, viral vectors, transgenic models, exercise and cardiac physiology (echocardiography, exercise testing, etc), and small animal heart failure and diabetes models (pharmacological and surgical interventions) will be acquired during this fellowship period.

Qualifications

QUALIFICATIONS:

A PhD in a basic science discipline is required, as well as a minimum two-year commitment. If interested in the position, please email a cover letter, CV, and three references to Dr. Haobo Li (email: haobo.li@mgh.harvard.edu).

EEO Statement

Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.